CAYSTON® Frequently Asked Questions (FAQs)

Answers to your questions about CAYSTON®

To get helpful questions to ask your care team, click where you are on your CAYSTON journey:

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Who should not take CAYSTON?

Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON.

What should I tell my doctor before taking CAYSTON?

Before taking CAYSTON, tell your doctor if you:

  • Are allergic to any antibiotics
  • Are pregnant or plan to become pregnant. It is not known if CAYSTON can harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. CAYSTON can pass into your breastmilk. Talk with your healthcare provider about the best way to feed your baby while you are taking CAYSTON.

Tell your doctor about all the medication you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how CAYSTON works.

How long does it take to nebulize a dose of CAYSTON?

Each nebulization should take about 2 to 3 minutes.*

*This does not include setting up, cleaning, and disinfecting your nebulizing equipment.

What are the most common side effects of CAYSTON?

The most common side effects of CAYSTON include cough, nasal congestion, wheezing, sore throat, fever (may be more common in children than in adults), chest discomfort, stomach area (abdominal) pain, and vomiting.

These are not all the possible side effects of CAYSTON. Tell your healthcare provider if you have any new or worsening symptoms while taking CAYSTON. Tell your healthcare provider about any side effect that bothers you or does not go away.

You can read the Important Safety Information for CAYSTON by clicking this link: Important Safety Information.

How and where do I get CAYSTON?

Talk to your CF care team to see if CAYSTON is right for you. If your CF care team does provide a CAYSTON prescription for you, visit the Important Steps When You Begin CAYSTON section of this website.

How long will it take to receive my first CAYSTON shipment?

Once the prescription has been received and processed by the select CAYSTON specialty pharmacy you choose to use, CAYSTON will be shipped to you directly via overnight mail. After ordering your CAYSTON, be sure to confirm a delivery date. If you do not take this step, your CAYSTON will not be delivered to your home.

Processing times may vary depending on your insurance; issues like a request for prior authorization and individual requirements for financial assistance may extend the processing time in some cases. For status updates on your specific situation, you can always talk directly to the specialty pharmacy or call the Cayston Access Program® at 1-877-7CAYSTON.

What will my first shipment of CAYSTON include?

Inside your first CAYSTON shipment you’ll find:

  • CAYSTON vials and saline ampules
  • An ALTERA® Nebulizer System, including the ALTERA Controller Unit and 2 handsets
  • Additional items or instructions that may come from your specialty pharmacy, such as brochures and other information

With each prescription refill, you will receive one box of CAYSTON and an additional ALTERA Nebulizer System handset.


Do I have to take each of my 3 CAYSTON doses at the same time every day?

No. The dosing of CAYSTON is flexible enough to allow you to fit it into your schedule as long as you take it 3 times a day with at least 4 hours in between each dose. To ensure that you get your complete dose of CAYSTON, make sure you are in an environment with a flat, stable surface to prepare your doses and sitting in an upright position to take your dose. To learn more, visit the Fitting CAYSTON Into Your Day section of the website.

Do I have to take my CAYSTON at home?

No. Because the ALTERA Nebulizer System is quiet, lightweight, and portable, you can take your daily supply of CAYSTON on the go, as long as you are in an environment with a flat, stable surface to prepare your dose and sitting in an upright position to take your dose.

do I have to take CAYSTON with food?

You can take each dose of CAYSTON with or without food.

How long will a course of CAYSTON last?

You should take CAYSTON as prescribed, in courses of 28 days on CAYSTON followed by 28 days off CAYSTON, as directed by your doctor.

Should I take CAYSTON with a Bronchodilator?

You should use an inhaled bronchodilator (a type of medicine used to relax and open your airways) before taking a dose of CAYSTON, as instructed by your doctor.

In what order should I take CAYSTON?

If you are taking several medicines to treat your cystic fibrosis, CAYSTON should be the last medicine or treatment you administer. You should take your medicines in this order:

  1. Bronchodilator
  2. Mucolytics (medicines to help clear mucus from your lungs like Pulmozyme® [dornase alfa] Inhalation Solution or Hypertonic Saline)

Take CAYSTON exactly as prescribed by your doctor.

What happens if I miss a dose of CAYSTON?

If you miss a dose of CAYSTON, you can still take all 3 daily doses as long as they are at least 4 hours apart.

Does CAYSTON need to be dose-adjusted for children?

No, the dose of CAYSTON is the same for both adults and children 7 years of age and older: one vial of CAYSTON, mixed with one ampule of saline (diluent) 3 times a day.

It is not known if CAYSTON is safe and effective in children under the age of 7 or in people with FEV1 <25% or >75% predicted.

Can i take a break or stop taking CAYSTON during my 28-day treatment course?

It is important for you to finish taking the full 28-day course of CAYSTON even if you are feeling better. If you skip doses or do not finish the full 28-day course of CAYSTON, your infection may not be fully treated and CAYSTON may not work as well as a treatment for Pa infection in the future.

Where and how should I store my CAYSTON after I start treatment?

CAYSTON can be stored at room temperature (up to 77 °F) and away from the light for up to 28 days after it has been removed from the refrigerator. For more information on storing CAYSTON, visit the Preparing CAYSTON section of the website.

Using the ALTERA® Nebulizer System

Can I take other medications through my ALTERA Nebulizer handset?

No, it is very important NOT to use any other medications in the ALTERA Nebulizer Handset. The use of drugs other than CAYSTON could result in incorrect dosage or overdoses of medication.

Additionally, CAYSTON should not be mixed with any other drugs in the ALTERA Nebulizer Handset. See the Preparing CAYSTON section of this website for more information.

What is the right way to clean and disinfect the ALTERA Nebulizer System?

Click here to see the detailed steps for cleaning and disinfecting the ALTERA Nebulizer System.


Inside your first shipment you will find the nebulizer system warranty card from the manufacturer (PARI). You can also find the warranty card here. It’s important to complete and submit the ALTERA warranty card to PARI so they can honor the 2-year limited warranty and additional 12-month extended warranty.

You can also contact the Cayston Access Program for help with issues with your nebulizer system.

Financial Support

What programs exist for people who are having trouble paying for CAYSTON?

The Cayston Access Program was established to provide financial assistance to uninsured or underinsured people who are experiencing financial difficulty accessing CAYSTON. The specialists at the program, who can be reached at 1-877-7CAYSTON between the hours of 8 AM – 8 PM EST, can review your unique situation and determine the best potential financial assistance solution for you.

For more information on financial assistance, click here.

Please click here to see complete Important Safety Information.

Please see full Prescribing Information, including Patient Information and Patient Instructions for Use.