In a Clinical Trial, Patients Taking Cayston for 28 Days Reported:
- Improved respiratory symptoms (ie, cough, wheezing, sputum production)
- An average 10% increase of their starting FEV1 (L) compared to placebo
- Fast nebulization time of about 2-3 minutes, 3 times a day, at least 4 hours apart
Cayston is approved based on three Phase 3 clinical studies with a total of 344 patients. To learn more about the design of the study, During the study, 80 people received Cayston 75 mg, 3 times a day, and 84 people received placebo (a substance containing no medication and which has no specific activity for the condition being treated) 3 times a day for 28 days by inhalation using the Altera® Nebulizer System. All participants used an inhaled bronchodilator (a medicine used to relax and open the airways) prior to receiving Cayston. Patients were receiving standard care for CF, including drugs to help with airway clearance. At the end of 28 days of treatment, the results for people who took Cayston were compared to those who took placebo.click here.
Talk to your healthcare provider to see if Cayston is right for you.
Important Safety Information
What is Cayston?
Cayston is a prescription inhaled antibiotic used to improve breathing symptoms in people with cystic fibrosis (CF) who have a lung infection due to Pseudomonas aeruginosa (Pa). Cayston is a treatment for infections caused by Pa, and not for infections caused by other bacteria or viruses, such as the common cold. It is not known if Cayston is safe and effective in children under the age of 7 or in patients with FEV1 <25% or >75% predicted.
Who should not take Cayston?
Do not take Cayston if you are allergic to aztreonam (AZACTAM®).
What are the possible side effects of Cayston?
Cayston can cause serious side effects, including:
- Severe allergic reactions. Stop your treatment with Cayston and call your doctor right away if you have any symptoms of an allergic reaction, including:
- Rash or swelling of your face
- Throat tightness
- Trouble breathing right after treatment with Cayston (bronchospasm). To decrease the chance of this happening, be sure to use your inhaled bronchodilator medicine before each treatment with Cayston. Stop treatment if chest tightness develops during nebulizer use.
- Decreases in FEV1 after 28-day course of treatment. Improvements that you experience in your lung function during your 28-day course of treatment may not be continued when you stop treatment.
Common side effects of Cayston include:
- Nasal congestion
- Sore throat
- Fever (may be more common in children than in adults)
- Chest discomfort
- Stomach area (abdominal) pain
Tell your doctor if you have any new or worsening symptoms while taking Cayston and about any side effects that bother you or that do not go away.
These are not all the possible side effects of Cayston. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
How should I take Cayston?
Take Cayston exactly as prescribed by your doctor.
The dose of Cayston for both adults and children 7 years of age and older is one vial of Cayston, mixed with one ampule of saline (diluent) 3 times a day. Doses of Cayston should be taken at least 4 hours apart. Cayston should be taken for 28 days, followed by at least 28 days off Cayston, as directed by your doctor.
Cayston is taken as a breathing treatment (inhalation) with the Altera Nebulizer System. Do not use any other nebulizer for your Cayston treatment. Do not mix Cayston with any other medicines in your Altera Nebulizer System. Do not mix Cayston with saline until right before you are ready to use it.
You should use an inhaled bronchodilator before taking a dose of Cayston. If you are taking several medicines or treatments to treat your cystic fibrosis, you should take your medicines or other treatments in this order: 1) bronchodilator, 2) mucolytics (medicines that help clear mucus from your lungs), and 3) Cayston.